abstract：BACKGROUND AND PURPOSE:The aim of our study was to describe patients with the p.D12Y variant (previously reported as D11Y) in SOD1 showing heterogeneous clinicopathological features. METHODS:We performed clinical, electrophysiological, magnetic resonance imaging (MRI) and muscle pathology studies in four SOD1 p.D12Y v...

journal_title：European journal of neurology

authors： Tasca G,Lattante S,Marangi G,Conte A,Bernardo D,Bisogni G,Mandich P,Zollino M,Ragozzino E,Udd B,Sabatelli M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuropsychiatric symptoms are commonly observed in neurodegenerative diseases. No biomarker is currently available to diagnose psychiatric conditions. As a consequence, the distinction between psychiatric and neurodegenerative disorders can be challenging in daily practice. METHODS:This retrospe...

journal_title：European journal of neurology

authors： Fourier A,Formaglio M,Kaczorowski F,Mollion H,Perret-Liaudet A,Sauvee M,Quadrio I

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphag...

journal_title：European journal of neurology

authors： Printza A,Boziki M,Bakirtzis C,Nikolaidis I,Kalaitzi M,Triaridis S,Grigoriadis N

更新日期：2020-07-01 00:00:00

abstract：BACKGROUNDAND PURPOSE:The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references. METHODS:The cohort consisted of 213 635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). 1215 individuals affected by ...

journal_title：European journal of neurology

authors： Canova C,Ludvigsson J,Barbiellini Amidei C,Zanier L,Zingone F

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We investigated the effectiveness of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS) patients with large vessel or distal occlusions and mild neurological deficits, defined as National Institutes of Health Stroke Scale scores < 6 points. METHODS:The primary efficacy outcome was 3-...

journal_title：European journal of neurology

authors： Tsivgoulis G,Goyal N,Katsanos AH,Malhotra K,Ishfaq MF,Pandhi A,Frohler MT,Spiotta AM,Anadani M,Psychogios M,Maus V,Siddiqui A,Waqas M,Schellinger PD,Groen M,Krogias C,Richter D,Saqqur M,Garcia-Bermejo P,Mokin M,Le

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...

journal_title：European journal of neurology

authors： Chen W,Xie Y,Zheng M,Lin J,Huang P,Pei Z,Yao X

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is large variability in the diagnostic approach and clinical management in functional movement disorders (FMD). This study aimed to examine whether opinions and clinical practices related to FMD have changed over the past decade. METHODS:Adapted from a 2008 version, we repeated the survey ...

journal_title：European journal of neurology

authors： LaFaver K,Lang AE,Stone J,Morgante F,Edwards M,Lidstone S,Maurer CW,Hallett M,Dwivedi AK,Espay AJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Anosognosia refers to a deficit of self-awareness or impaired insight for cognitive and behavioral problems. Cognitive anosognosia was explored in de novo patients with Parkinson's disease (PD) and its relationship to cognitive function and neuropsychiatric symptoms was investigated. METHODS:The...

journal_title：European journal of neurology

authors： Yoo HS,Chung SJ,Lee YH,Ye BS,Sohn YH,Lee PH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subjective cognitive decline (SCD) is a self-experienced decline in cognitive capacity with normal performance on standardized cognitive tests and has been shown to increase the risk of Alzheimer's disease (AD). SCD could also be related to other conditions such as normal aging, psychiatric, neur...

journal_title：European journal of neurology

authors： Mazzeo S,Padiglioni S,Bagnoli S,Carraro M,Piaceri I,Bracco L,Nacmias B,Sorbi S,Bessi V

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim was to explore the risk of early stroke recurrence within 3 months after watershed infarction and to investigate whether early dual antiplatelet therapy is more effective in decreasing such risk. METHODS:Patients enrolled in the Clopidogrel in High-risk Patients with Acute Non-disabling ...

journal_title：European journal of neurology

authors： Pu Y,Liu X,Wang Y,Meng X,Jing J,Zou X,Pan Y,Wang A,Zhao X,Johnston SC,Wang Y,Atchaneeyasakul K,Liebeskind DS,Liu L,CHANCE Investigators.

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transorbital sonography (TOS) has emerged as promising imaging method for the diagnosis and follow-up of acute optic neuritis (ON). Available studies report an increase in the optic nerve diameter (OND) and the optic nerve sheath diameter (ONSD) in the case of a first episode of ON in the affecte...

journal_title：European journal of neurology

authors： Schroeder C,Katsanos AH,Ayzenberg I,Schwake C,Gahlen A,Tsivgoulis G,Voumvourakis K,Gold R,Krogias C

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Humanized monoclonal antibody galcanezumab, which binds to calcitonin-gene-related peptide, has shown efficacy for episodic and chronic migraine prevention. These analyses evaluated galcanezumab response for migraine headache prevention in patients who previously failed onabotulinumtoxinA ('nonre...

journal_title：European journal of neurology

authors： Ailani J,Pearlman E,Zhang Q,Nagy AJ,Schuh K,Aurora SK

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is well established that patient-related constitutional features predispose to focal peripheral neuropathies. Some of these risk factors were investigated in common focal neuropathies encountered in patients referred for electromyography. METHODS:Gender, age, height and body mass index (BMI) ...

journal_title：European journal of neurology

authors： Martínez-Aparicio C,Jääskeläinen SK,Puksa L,Reche-Lorite F,Torné-Poyatos P,Paniagua Soto J,Falck B

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dermatomyositis (DM) with anti-nuclear matrix protein-2 (NXP-2) antibodies usually shows multifocal ischaemic lesions in muscle. Here, we aimed to investigate the microarteriopathy underlying muscle ischaemia in anti-NXP-2-positive DM. METHODS:A total of 16 patients diagnosed with anti-NXP-2-pos...

journal_title：European journal of neurology

authors： Liu Y,Zheng Y,Gang Q,Xie Z,Jin Y,Zhang X,Deng X,Hao H,Gao F,Zhang Z,Xiong H,Zhang W,Wang Z,Yuan Y

更新日期：2020-03-01 00:00:00

abstract：:This paper describes 10 core features of a neuropsychological assessment with the aim of helping neurologists understand the unique contribution the evaluation can make within the wider context of diagnostic methods in epilepsy. The possibilities, limitations and cautions associated with the investigation are discusse...

journal_title：European journal of neurology

authors： Baxendale SA,Wilson SJ,Baker GA,Barr W,Helmstaedter C,Hermann BP,Langfitt J,Reuner G,Rzezak P,Samson S,Smith ML

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder with varied prevalence in different populations, which may be associated with specific haplotypes. This study aimed to explore the haplotypes encompassing the HTT gene in the Chinese population. METHODS:A total of 406...

journal_title：European journal of neurology

authors： Li XY,Li HL,Dong Y,Gao B,Cheng HR,Ni W,Gan SR,Liu ZJ,Burgunder JM,Wu ZY

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The prognostic value of serum neurofilament light chain (sNfL), a biomarker of neurodegeneration, compared to other prognostic factors of amyotrophic lateral sclerosis (ALS) at the time of diagnosis, remains unclear. METHODS:Sera from ALS patients were prospectively collected at the first diagno...

journal_title：European journal of neurology

authors： Thouvenot E,Demattei C,Lehmann S,Maceski-Maleska A,Hirtz C,Juntas-Morales R,Pageot N,Esselin F,Alphandéry S,Vincent T,Camu W

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose was to identify statistically factors that correlate with the presence of a colony-stimulating factor 1 receptor (CSF1R) mutation and to reevaluate the accuracy of the current diagnostic criteria for CSF1R-related leukoencephalopathy. METHODS:CSF1R testing was conducted on 145 consec...

journal_title：European journal of neurology

authors： Kondo Y,Matsushima A,Nagasaki S,Nakamura K,Sekijima Y,Yoshida K

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim was to study the prevalence of epilepsy in a hospital-based systemic lupus erythematosus (SLE) cohort and to investigate the relationship between epilepsy and other manifestations of neuropsychiatric SLE (NPSLE). METHODS:The study population consisted of 440 SLE patients recruited from 1...

journal_title：European journal of neurology

authors： Hopia L,Andersson M,Svenungsson E,Khademi M,Piehl F,Tomson T

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS:Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with...

journal_title：European journal of neurology

authors： Doneddu PE,Bianchi E,Cocito D,Manganelli F,Fazio R,Filosto M,Mazzeo A,Cosentino G,Cortese A,Jann S,Clerici AM,Antonini G,Siciliano G,Luigetti M,Marfia GA,Briani C,Lauria G,Rosso T,Cavaletti G,Carpo M,Benedetti L,

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Whether the neuromelanin-positive substantia nigra pars compacta area (NM-SNc) on neuromelanin magnetic resonance imaging (NM-MRI) and the specific binding ratio (SBR) on 123 I-N-v-fluoropropyl-2b-carbomethoxy3b-(4-iodophenyl)nortropane single photon emission computed tomography (DaT-SPECT) can b...

journal_title：European journal of neurology

authors： Okuzumi A,Hatano T,Kamagata K,Hori M,Mori A,Oji Y,Taniguchi D,Daida K,Shimo Y,Yanagisawa N,Nojiri S,Aoki S,Hattori N

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischaemic stroke frequently has a cardioembolic (CE) source. Clinical and echocardiographic parameters associated with CE stroke were evaluated. METHODS:In all, 93 consecutive ischaemic stroke patients who underwent a transthoracic echocardiogram were retrospectively analysed; strokes were class...

journal_title：European journal of neurology

authors： Ferkh A,Brown P,O'Keefe E,Zada M,Duggins A,Thiagalingam A,Altman M,Boyd A,Byth K,Kizana E,Denniss AR,Thomas L

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low-density lipoprotein (oxLDL), oxLDL:high-density lipoprotein (HDL) and oxLDL:low-density lipoprotein (LDL), with functional outcome of minor stroke ...

journal_title：European journal of neurology

authors： Wang A,Zhang X,Li S,Zhao X,Liu L,Johnston SC,Meng X,Lin J,Zuo Y,Li H,Wang Y,Wang Y,CHANCE Study Group.

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The expanded repeat length in ATXN1 negatively correlates with age at onset (AAO) of spinocerebellar ataxia type 1 (SCA1) but can explain only part of it, indicating that other factors affect AAO. Some studies have explored the influence of non-causative CAG repeats on the AAO of SCA patients. Ho...

journal_title：European journal of neurology

authors： Wang P,Chen Z,Peng Y,Cao L,Li X,Wang C,Yang H,Peng H,Shi Y,Zhou X,Li T,Feng L,Wu C,Qiu R,Xia K,Tang B,Jiang H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevation of cardiac troponin (cTn), a sensitive biomarker of myocardial injury, is frequently observed in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA). Until now, no study has systematically asse...

journal_title：European journal of neurology

authors： Erdur H,Siegerink B,Ganeshan R,Audebert HJ,Endres M,Nolte CH,Scheitz JF

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The multiple sclerosis prodrome remains poorly understood. We aimed to examine the prodrome in people with relapsing remitting multiple sclerosis at onset (RMS) and primary progressive multiple sclerosis (PPMS). METHODS:We conducted a matched cohort study using clinical and linked health adminis...

journal_title：European journal of neurology

authors： Wijnands JMA,Zhu F,Kingwell E,Zhao Y,Evans C,Fisk JD,Marrie RA,Tremlett H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to examine the association amongst remote diffusion-weighted imaging lesions (R-DWILs), imaging markers of cerebral small vessel disease (cSVD) and total cSVD burden in patients with primary intracerebral haemorrhage (ICH). METHODS:In total, 344 consecutive primary ICH ...

journal_title：European journal of neurology

authors： Xu XH,Ye XH,Li JW,Cai JS,Gao T,Zhang WJ,Zhao GH,Tong LS,Gao F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut-off value of pRNFL thinning rates in relapsing-remitting MS (RRMS) to discriminate between stable and progressing patien...

journal_title：European journal of neurology

authors： Bsteh G,Hegen H,Teuchner B,Berek K,Wurth S,Auer M,Di Pauli F,Deisenhammer F,Berger T

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We previously reported that certain optical coherence tomography (OCT) measures were sensitive and reliable in identifying idiopathic intracranial hypertension (IIH). This prospective study aimed to define OCT measures that allow differentiation of IIH with and without papilledema, thereby helpin...

journal_title：European journal of neurology

authors： Huang-Link Y,Eleftheriou A,Yang G,Johansson JM,Apostolou A,Link H,Jin YP

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose was to evaluate the association between the left ventricular ejection fraction (LVEF) and cerebral small vessel disease (cSVD) in ischaemic stroke patients. METHODS:Consecutive first-ever ischaemic stroke patients between 2010 and 2013 were included. White matter hyperintensity (WMH)...

journal_title：European journal of neurology

authors： Nam KW,Kwon HM,Kim HL,Lee YS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Predicting the course of behavioural variant frontotemporal dementia (bvFTD) remains a major clinical challenge. This study aimed to identify factors that predict survival and clinical progression in bvFTD. METHODS:Consecutive patients with clinically probable bvFTD were prospectively followed u...

journal_title：European journal of neurology

authors： Agarwal S,Ahmed RM,D'Mello M,Foxe D,Kaizik C,Kiernan MC,Halliday GM,Piguet O,Hodges JR

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...

journal_title：European journal of neurology

authors： Toscano M,Viganò A,Rea A,Verzina A,Sasso D'Elia T,Puledda F,Longo L,Mancini V,Ruggiero M,Jannini TB,Giuliani G,Albino F,Altieri M,Vicenzini E,Fattapposta F,Pauri F,Giacomini P,Ruoppolo G,Di Piero V

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diffusion-weighted imaging (DWI) commonly detects acute ischaemic lesions in patients with acute intracerebral hemorrhage (ICH), especially with cerebral amyloid angiopathy (CAA). We investigated the relationship between cortical superficial siderosis (cSS), a neuroimaging marker of CAA, and DWI ...

journal_title：European journal of neurology

authors： Revel-Mouroz P,Viguier A,Cazzola V,Calviere L,Patsoura S,Rousseau V,Sommet A,Albucher JF,Cognard C,Olivot JM,Bonneville F,Raposo N

更新日期：2019-04-01 00:00:00

abstract：:The clinical outcomes of isocitrate dehydrogenase-wild-type (IDH-wt) lower-grade glioma (LGG) have been the subject of debate for some time. In this meta-analysis, we aimed to assess the prognostic values of several known genetic markers (e.g. TERT promoter mutation, H3F3A mutation, CDKN2A loss) in this tumor group. F...

journal_title：European journal of neurology

authors： Vuong HG,Tran TTK,Ngo HTT,Pham TQ,Nakazawa T,Fung KM,Hassell L,Katoh R,Kondo T

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fabry disease is an X-linked disease, and enzyme-based screening methods are not suitable for female patients. METHODS:In total, 1000 young stroke patients (18-55 years, 661 with ischaemic stroke and 339 with hypertensive intracerebral hemorrhage) were recruited. The Sequenom iPLEX assay was use...

journal_title：European journal of neurology

authors： Lee TH,Yang JT,Lee JD,Chang KC,Peng TI,Chang TY,Huang KL,Liu CH,Ryu SJ,Burlina AP

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Friedreich's ataxia (FRDA) is the most common autosomal-recessive ataxia worldwide. It is characterized by early onset, sensory abnormalities and slowly progressive ataxia. All magnetic resonance imaging (MRI)-based studies have focused on the evaluation of adult patients. Therefore, we designed ...

journal_title：European journal of neurology

authors： Rezende TJR,Martinez ARM,Faber I,Girotto Takazaki KA,Martins MP,de Lima FD,Lopes-Cendes I,Cendes F,França MC Jr

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In contrast to anterior circulation stroke (ACS), there is no evidence from randomized trials that mechanical thrombectomy (MT) with modern stent retrievers or thromboaspiration is safe and effective in posterior circulation stroke (PCS). METHODS:The present analysis was based on the prospective...

journal_title：European journal of neurology

authors： Weber R,Minnerup J,Nordmeyer H,Eyding J,Krogias C,Hadisurya J,Berger K,REVASK investigators.

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:CACNA1A encodes the α1 subunit of the neuronal calcium channel P/Q. CACNA1A mutations underlie three allelic disorders: familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6). A clear-cut genotype-phenotype correlation is often lacking si...

journal_title：European journal of neurology

authors： Indelicato E,Nachbauer W,Karner E,Eigentler A,Wagner M,Unterberger I,Poewe W,Delazer M,Boesch S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Body mass index (BMI), hyperglycaemia and type 2 diabetes and their interactive effects are associated with brain volume atrophy in ageing. It remains to be established if these risk factors are particularly concerning in individuals with high or low brain volumes. METHODS:Demographics, venous b...

journal_title：European journal of neurology

authors： Walsh EI,Shaw M,Sachdev P,Anstey KJ,Cherbuin N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients suffering from basilar artery occlusion (BAO) and treated with intravenous thrombolysis are, in some centers, started on adjunct anticoagulation in hyperacute settings. We aimed to assess the outcome of such patients and to compare low-molecular weight heparin (LMWH) and unfractionated h...

journal_title：European journal of neurology

authors： Ritvonen J,Strbian D,Silvennoinen H,Virtanen P,Salonen O,Lindsberg PJ,Sairanen T

更新日期：2019-01-01 00:00:00